Journal: Biomedicines
Article Title: Semaglutide Prevents Aortic Rupture and Dissection in the Angiotensin II Mouse Model
doi: 10.3390/biomedicines14040933
Figure Lengend Snippet: MALDI mass spectrometry imaging of the three experimental groups. ( A ) Glutathione (GSH) at m / z 306.0768 [M-H] − , obtained by met-ID and confirmed from MSMS-fragmentation ( p = 0.032); ( B ) glutathione (GSSG) at m / z 611.1440 [M-H] − , identified based on accurate mass ( p = 0.2443); ( C ) cholesterol sulphate at m / z 465.3049 [M-H] − ( p = 0.050); and ( D ) sphingomyelin (33:1) at m / z 687.5452 [M-H] − ( p = 0.009), obtained by met-ID, respectively. Coloration of the respective group regions is given at the bottom of the figure. AS: angII + semaglutide; AV: angII + vehicle; SV: saline + vehicle. Box-plots and p -values were obtained from one-way ANOVA of the three groups.
Article Snippet: Peak m / z recalibration and preliminary metabolite identification were performed by using accurate mass measurements and the in-house developed software Met-ID (version 0.5.8) [ ] which includes searchable metabolites entries from the Human Metabolome Database (HMDB) [ ] and LIPID MAPS [ , ].
Techniques: Mass Spectrometry, Imaging, Saline